Solvothermal synthesis and characterization of ytterbium/iron mixed oxide nanoparticles with potential functionalities for applications as multiplatform contrast agent in medical image techniques

Author(s)
M.P. Yeste, C. Fernández-Ponce, E. Félix, M. Tinoco, R. Fernández-Cisnal, C. García-Villar, Cathrin Pfaff, Jürgen Kriwet, E. Natividad, M.A. Cauqui, F. Garcia-Cozar, R. Litrán, O. Bomati-Miguel
Abstract

A solvothermal route to prepare Glutathione capped hybrid ytterbium/iron oxide nanoparticles with potential applications as multiplatform contrast agent in medical image techniques has been developed. The influence of ytterbium/iron molar ratio used as precursor, as well as the degree of the autoclave filling on the structural and morphological characteristics of the obtained nanoparticles has been extensively studied. Although all nanoparticles present similar composition, with YbFeO

3 being the majority phase, size and morphology of the as synthetized nanoparticles are highly influenced by the critical temperature and by the over -saturation reached during the solvothermal process. We have demonstrated that glutathione properly functionalizes the hybrid nanoparticles, increasing their colloidal stability and decreasing their cytotoxicity. Additionally, they show good imaging in magnetic resonance and X-ray computerized tomography, thereby indicating promising potential as a dual contrast agent. This work presents, for the first time, glutathione functionalized ytterbium/iron oxide nanoparticles with potential applications in Biomedicine.

Organisation(s)
Department of Evolutionary Biology, Department of Palaeontology
External organisation(s)
University of Cádiz, Universidad Complutense De Madrid, Hospital Universitario Puerta del Mar, Universidad de Zaragoza, Cadiz Institute of Biomedical Research
Journal
Ceramics International
Volume
48
Pages
31191–31202
No. of pages
12
ISSN
0272-8842
DOI
https://doi.org/10.1016/j.ceramint.2022.06.194
Publication date
11-2022
Peer reviewed
Yes
Austrian Fields of Science 2012
105118 Palaeontology
Keywords
ASJC Scopus subject areas
Electronic, Optical and Magnetic Materials, Ceramics and Composites, Materials Chemistry, Surfaces, Coatings and Films, Process Chemistry and Technology
Portal url
https://ucris.univie.ac.at/portal/en/publications/solvothermal-synthesis-and-characterization-of-ytterbiumiron-mixed-oxide-nanoparticles-with-potential-functionalities-for-applications-as-multiplatform-contrast-agent-in-medical-image-techniques(4f008404-90fc-44e8-a413-2fa257f7f65c).html