Total Synthesis, Stereochemical Assignment, and Divergent Enantioselective Enzymatic Recognition of Larreatricin
- Autor(en)
- Harry J. Martin, Ioannis Kampatsikas, Rik Oost, Matthias Pretzler, Emir Al-Sayed, Alexander Roller, Gerald Giester, Annette Rompel, Nuno Maulide
- Abstrakt
A concise and efficient total synthesis of the lignan natural product larreatricin as well as an unambiguous assignment of configuration of its enantiomers are reported, resolving a long-held controversy. Enzyme kinetic studies revealed that different polyphenol oxidases show high and remarkably divergent enantioselective recognition of this secondary metabolite.
- Organisation(en)
- Institut für Organische Chemie, Institut für Biophysikalische Chemie, Core Facility für Kristallstrukturanalyse, Institut für Anorganische Chemie, Institut für Mineralogie und Kristallographie
- Journal
- Chemistry: A European Journal
- Band
- 24
- Seiten
- 15756-15760
- Anzahl der Seiten
- 5
- ISSN
- 0947-6539
- DOI
- https://doi.org/10.1002/chem.201803785
- Publikationsdatum
- 10-2018
- Peer-reviewed
- Ja
- ÖFOS 2012
- 104015 Organische Chemie, 104024 Röntgenstrukturanalyse, 105113 Kristallographie
- Schlagwörter
- ASJC Scopus Sachgebiete
- Catalysis, Organic Chemistry
- Link zum Portal
- https://ucrisportal.univie.ac.at/de/publications/69dd9de5-7a23-45b9-a34d-73a8a4250de8