Synthesis, crystal structure and biological characterization of a novel palladium(II) complex with a coumarin-derived ligand
- Autor(en)
- Elzbieta Budzisz, Bernhard Keppler, Gerald Giester, Magdalena Wozniczka, Aleksander Kufelnicki, Barbara Nawrot
- Abstrakt
Methyl 2-methyl-4-oxo-4H-chromene-3-carboxylate (1) was treated with 25% aqueous ammonia to give 3-(1-aminoethylidene)-2H-chromene-2,4(3H)-dione (2). Compound 2 was used as a ligand for the formation of a palladium(II) complex. The structures of the ligand and its palladium complex 3 were determined by IR and 1H NMR spectroscopy, FAB mass spectrometry and elemental analysis. The single-crystal X-ray structure of 3 was also solved. Ligand 2 in 20% dioxane solution shows two protonation constants - log ß11 = 4.28 ‘ 0.01 and log ß12 = 7.66 ‘ 0.03. In complex 3 two ligand molecules chelate to the Pd ion through their N and O donors, giving a four-coordinate PdII center with a cis-N2O 2 donor set. The coordination geometry at PdII is square-planar with typical values for the distances from the Pd atom to the coordinated atoms. The cytotoxicity of compound 3 was determined on three cancer cell lines. IC50 values of 9.7, 7.8 and 7.8 nM were found for A546, HeLa and K562 cells, respectively, which is notably lower than carboplatin, which shows corresponding IC50 values of 105.98, 73.49 and 60.92 œM. Double-stranded DNA treated with 3 shows a significant increase in the ?e value in the CD spectra, as well as a lower electrophoretic mobility than parent DNA. Œ Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
- Organisation(en)
- Institut für Anorganische Chemie, Institut für Mineralogie und Kristallographie
- Externe Organisation(en)
- Medical University of Lodz, Polish Academy of Sciences (PAS)
- Journal
- European Journal of Inorganic Chemistry
- Seiten
- 4412-4419
- Anzahl der Seiten
- 8
- ISSN
- 1434-1948
- Publikationsdatum
- 2004
- Peer-reviewed
- Ja
- ÖFOS 2012
- 1051 Geologie, Mineralogie
- Sustainable Development Goals
- SDG 3 – Gesundheit und Wohlergehen
- Link zum Portal
- https://ucrisportal.univie.ac.at/de/publications/8e7e0f78-41ff-40eb-b9ae-236d405c0c55