A uniform measurement expression for cross method comparison of nanoparticle aggregate size distributions

Autor(en)

Agnieszka Dudkiewicz, Stephan Wagner, Angela Lehner, Qasim Chaudhry, Stephane Pietravalle, Karen Tiede, Alistair B. A. Boxall, Guenter Allmaier, Dirk Tiede, Ringo Grombe, Frank von der Kammer, Thilo Hofmann, Kristian Molhave

Abstrakt

Available measurement methods for nanomaterials are based on very different measurement principles and hence produce different values when used on aggregated nanoparticle dispersions. This paper provides a solution for relating measurements of nanomaterials comprised of nanoparticle aggregates determined by different techniques using a uniform expression of a mass equivalent diameter (MED). The obtained solution is used to transform into MED the size distributions of the same sample of synthetic amorphous silica (nanomaterial comprising aggregated nanoparticles) measured by six different techniques: scanning electron microscopy in both high vacuum (SEM) and liquid cell setup (Wet-SEM); gas-phase electrophoretic mobility molecular analyzer (GEMMA); centrifugal liquid sedimentation (CLS); nanoparticle tracking analysis (NTA); and asymmetric flow field flow fractionation with inductively coupled plasma mass spectrometry detection (AF4-ICP-MS). Transformed size distributions are then compared between the methods and conclusions drawn on methods’ measurement accuracy, limits of detection and quantification related to the synthetic amorphous silca's size. Two out of the six tested methods (GEMMA and AF4-ICP-MS) cross validate the MED distributions between each other, providing a true measurement. The measurement accuracy of other four techniques is shown to be compromised either by the high limit of detection and quantification (CLS, NTA, Wet-SEM) or the sample preparation that is biased by increased retention of smaller nanomaterials (SEM). This study thereby presents a successful and conclusive cross-method comparison of size distribution measurements of aggregated nanomaterials. The authors recommend the uniform MED size expression for application in nanomaterial risk assessment studies and clarifications in current regulations and definitions concerning nanomaterials.

Organisation(en)

Externe Organisation(en)

The Food and Environment Research Agency, Paris-Lodron Universität Salzburg, Technical University of Denmark (DTU), Technische Universität Wien, University of York, European Commission Joint Research Centre

Journal

The Analyst

Band

140

Seiten

5257-5267

Anzahl der Seiten

11

ISSN

0003-2654

DOI

https://doi.org/10.1039/c5an00561b

Publikationsdatum

06-2015

Peer-reviewed

Ja

ÖFOS 2012

104023 Umweltchemie, 104002 Analytische Chemie, 105906 Umweltgeowissenschaften, 210004 Nanomaterialien

Schlagwörter

ASJC Scopus Sachgebiete

Analytical Chemistry, Biochemistry, Spectroscopy, Electrochemistry, Environmental Chemistry

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/a-uniform-measurement-expression-for-cross-method-comparison-of-nanoparticle-aggregate-size-distributions(9bfeb25b-6de8-447d-a909-3bc848b14b01).html