[RuCl3ind3] and [RuCl2ind4]: Two new ruthenium complexes derived from the tumor-inhibiting RuIII compound HInd (OC-6-11)-[RuCl4ind2] (ind = indazole)

Autor(en)

Thomas Pieper, Martina Sommer, Mathea Sophia Galanski, Bernhard Keppler, Gerald Giester

Abstrakt

Indazolium (OC-6-11)-tetrachlorobis(indazole) ruthenate(III), HInd (OC-6-11)-[RuCl4ind2], exhibits excellent results in different tumor models in vitro and in vivo. Substitution reactions of this ruthenium(III) complex are of special interest for a deeper understanding of its interactions with biologically occurring targets and its mode of action. The indazolium complex salt can be transformed to the neutral, meridionally configurated trisindazole complex (OC-6-21)-[RuCl3ind3] in solvents like tetrahydrofuran. The X-ray crystal structure of this complex could be solved (monoclinic space group P2(1)/n, a = 12.441(3), b = 10.415(3), c = 21.635(4) A°, ß = 105.02(1)°). In spite of the paramagnetic RuIII atom most of the coordinated indazole protons could be assigned with the help of two-dimensional NMR experiments. Additionally, a reduced reaction product of HInd (OC-6-11)-[RuCl4ind2] in the physiological solubilizer 2-pyrrolidone could be isolated and the X-ray crystal structure of this RuII complex, (OC-6-12)-[RuCl2ind4], crystallized with two 2-pyrrolidones, could be solved (monoclinic space group P2(1)/n, a = 12.139(2), b = 10.426(2), c = 14.426(3) A°, ß = 100.06(3)°). Œ WILEY-VCH Verlag GmbH, D-69451 Weinheim, 2001.

Organisation(en)

Institut für Anorganische Chemie, Institut für Mineralogie und Kristallographie

Externe Organisation(en)

Universität Wien

Journal

Zeitschrift für Anorganische und Allgemeine Chemie

Band

627

Seiten

261-265

Anzahl der Seiten

5

ISSN

0044-2313

DOI

https://doi.org/10.1002/1521-3749(200102)627:2<261::AID-ZAAC261>3.0.CO;2-K

Publikationsdatum

2001

Peer-reviewed

Ja

ÖFOS 2012

1051 Geologie, Mineralogie

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/b011e295-3818-4efa-a9da-19308e04e8d3