Cover Feature: Total Synthesis, Stereochemical Assignment, and Divergent Enantioselective Enzymatic Recognition of Larreatricin (Chem. Eur. J. 59/2018)
- Autor(en)
- Harry J. Martin, Ioannis Kampatsikas, Rik Oost, Matthias Pretzler, Emir Al-Sayed, Alexander Roller, Gerald Giester, Annette Rompel, Nuno Maulide
- Abstrakt
Mirror, mirror on the wall, who is the fairest one of all? Larreatricin is a naturally occurring lignan with a long history of use in traditional medicine. However, its absolute configuration remains unknown and its biological activity is poorly understood. An efficient total synthesis allowing for the unambiguous assignment of the configuration of its enantiomers is presented. Polyphenol oxidases show high and remarkably divergent enantioselective recognition of this secondary metabolite. More information can be found in the Communication by H. J. Martin, A. Rompel, N. Maulide et al. on page 15756.
- Organisation(en)
- Institut für Organische Chemie, Institut für Biophysikalische Chemie, Core Facility für Kristallstrukturanalyse, Institut für Anorganische Chemie, Institut für Mineralogie und Kristallographie
- DOI
- https://doi.org/10.1002/chem.201805128
- Publikationsdatum
- 10-2018
- ÖFOS 2012
- 104015 Organische Chemie, 104024 Röntgenstrukturanalyse, 105113 Kristallographie
- Schlagwörter
- Link zum Portal
- https://ucrisportal.univie.ac.at/de/publications/c8c52c38-3301-49ec-81f1-e067c9822dae