Nanoparticle functionalized polyplexes: efficient nucleic acid delivery platform and theranostic applications
- Author(s)
- Haider Sami, Alexander Taschauer, Nathalie Tepe, Simon Decker, Norbert Cyran, Martina Anton, Thilo Hofmann, Andrey Rogach, Manfred Ogris
- Abstract
Introduction: Nanomedicine has significant potential for nucleic acid delivery and -therapy, but also faces challenges, both on the cellular level and in vivo [1]. Real-time tracking of nanocarriers in vivo can aid in identifying bot-tlenecks. The present work aims to address the above challenges by synthesizing polyplexes (complexes of nucleic acids with cationic poly-mers) functionalized with a) gold nanoparticles for small interfering RNA (siRNA) delivery (au-ropolyplexes; APxs) and b) quantum dots (QDs) for imageable gene delivery (quantopol-yplexes; QPxs).
- Organisation(s)
- External organisation(s)
- Technische Universität München, City University of Hong Kong (CityU)
- No. of pages
- 1
- Publication date
- 2019
- Austrian Fields of Science 2012
- 105906 Environmental geosciences
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/290cb5a2-d57e-4ef1-a82a-eebc5303a750