Complexes of N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid with group 12 metals and vanadium-Synthesis, structure and bioactivity of the vanadium complex
- Author(s)
- Ladislav Habala, Caroline Bartel, Gerald Giester, Michael A. Jakupec, Bernhard K. Keppler, Annette Rompel
- Abstract
Four new complexes of group 12 metals [Zn(II), Cd(II) and Hg(II)], along with vanadyl bound to the ligand N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid, have been synthesized and characterized. The structure of the complexes with Zn(II), Hg(II) and V(IV) was determined by X-ray structural analysis. In all observed cases, the symmetry of these complexes was found to be distorted octahedral. The inhibition of protein tyrosine phosphatase 1B by the vanadium(IV) complex was demonstrated. The cytotoxicity of the vanadium(IV) complex was tested in vitro against three cancer cell lines, with a comparison of the activity of the free ligand and of vanadyl acetylacetonate and sodium orthovanadate. The IC
50 values of the complex were in the range of 9 to 21 μM. Remarkably, cytotoxic potency in the multidrug-resistant non-small cell lung cancer cell line A549 was at least as high as in the broadly chemosensitive ovarian teratocarcinoma cell line CH1(PA-1).
- Organisation(s)
- Department of Biophysical Chemistry, Department of Inorganic Chemistry, Department of Mineralogy and Crystallography
- Journal
- Journal of Inorganic Biochemistry
- Volume
- 147
- Pages
- 147-152
- No. of pages
- 6
- ISSN
- 0162-0134
- Publication date
- 04-2015
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 106002 Biochemistry, 105113 Crystallography
- Keywords
- ASJC Scopus subject areas
- Biochemistry, Inorganic Chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/complexes-of-nhydroxyethylnbenzimidazolylmethylethylenediaminediacetic-acid-with-group-12-metals-and-vanadiumsynthesis-structure-and-bioactivity-of-the-vanadium-complex(383cbc5f-ee70-4bac-9c96-48382325e84d).html