Refinement of the selection of physicochemical properties for grouping and read-across of nanoforms
- Author(s)
- Frédéric Loosli, Kirsten Rasmussen, Hubert Rauscher, Richard K Cross, Nathan Bossa, Willie Peijnenburg, Josje Arts, Marianne Matzke, Claus Svendsen, David Spurgeon, Per Axel Clausen, Emmanuel Ruggiero, Wendel Wohlleben, Frank von der Kammer
- Abstract
Before placing a new nanoform (NF) on the market, its potential adverse effects must be evaluated. This may e.g. be done via hazard and risk assessment. Grouping and read-across of NFs is a possible strategy to reduce resource consumption, maximising the use of existing data for assessment of NFs. The GRACIOUS project provides a framework in which possible grouping and read-across for NFs is mainly based on an evaluation of their similarity. The impact of NFs on human health and the environment depends strongly on the concentration of the NF and its physicochemical properties, such as chemical composition, size distribution, shape, etc. Hence, knowledge of the most relevant physicochemical properties is essential information for comparing similarity. The presented work aims to refine existing proposals for sets of descriptors (descriptor array) that are needed to describe distinct NFs of a material to identify the most relevant ones for grouping and read-across. The selection criteria for refining this descriptor array are explained and demonstrated. Relevant protocols and methods are proposed for each physicochemical property. The required and achievable measurement accuracies of the refined descriptor array are reviewed, as this information is necessary for similarity assessment of NFs based on individual physicochemical properties.
- Organisation(s)
- Department of Environmental Geosciences
- External organisation(s)
- Institute for Environment and Sustainability , Centre for Ecology and Hydrology, LEITAT Technological Center, Carrer de la Innovació 2, 08225 Terrassa, Barcelona, Spain., Nouryon, Bohus, Sweden., The National Research Centre for the Working Environment (NFA), Lersø Parkallé 105, 2100 Copenhagen East, Denmark., BASF SE, Leiden University, National Institute of Public Health and the Environment
- Journal
- NanoImpact
- Volume
- 25
- No. of pages
- 10
- ISSN
- 2452-0748
- DOI
- https://doi.org/10.1016/j.impact.2021.100375
- Publication date
- 01-2022
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 105906 Environmental geosciences
- Keywords
- ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health, Safety, Risk, Reliability and Quality, Safety Research, Materials Science (miscellaneous)
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/3aaea32a-50c8-4b6e-9341-f68eae438319