Production of reference materials for the detection and size determination of silica nanoparticles in tomato soup
- Author(s)
- Ringo Grombe, Jean Charoud-Got, Håkan Emteborg, Thomas P J Linsinger, John Seghers, Stephan Wagner, Frank von der Kammer, Thilo Hofmann, Agnieszka Dudkiewicz, Meritxell Llinas, Conxita Solans, Angela Lehner, Günter Allmaier
- Abstract
A set of four reference materials for the detection and quantification of silica nanoparticles (NPs) in food was produced as a proof of principle exercise. Neat silica suspensions were ampouled, tested for homogeneity and stability, and characterized for total silica content as well as particle diameter by dynamic light scattering (DLS), electron microscopy (EM), gas-phase electrophoretic molecular mobility analysis (GEMMA), and field-flow fractionation coupled with an inductively coupled mass spectrometer (FFF-ICPMS). Tomato soup was prepared from ingredients free of engineered nanoparticles and was spiked at two concentration levels with the silica NP suspension. Homogeneity of these materials was found sufficient to act as reference materials and the materials are sufficiently stable to allow long-term storage and distribution at ambient temperature, providing proof of principle of the feasibility of producing liquid food reference materials for the detection of nanoparticles. The spiked soups were characterized for particle diameter by EM and FFF-ICPMS (one material only), as well as for the total silica content. Although questions regarding the trueness of the results from EM and FFF-ICPMS procedures remain, the data obtained indicate that even assigning values should eventually be feasible. The materials can therefore be regarded as the first step towards certified reference materials for silica nanoparticles in a food matrix.
- Organisation(s)
- External organisation(s)
- Commiss European Communities, Joint Res Ctr, Inst Reference Mat & Measurements, Spanish National Research Council (CSIC), Technische Universität Wien, University of York, The Food and Environment Research Agency
- Journal
- Analytical and Bioanalytical Chemistry
- Volume
- 406
- Pages
- 3895-3907
- No. of pages
- 13
- ISSN
- 1618-2642
- DOI
- https://doi.org/10.1007/s00216-013-7554-1
- Publication date
- 06-2014
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 210001 Nanoanalytics, 104023 Environmental chemistry, 104002 Analytical chemistry, 210006 Nanotechnology
- Keywords
- ASJC Scopus subject areas
- Analytical Chemistry, Biochemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/ab5c9147-3191-4232-9b7d-c07e446e90e9