The ERC Proof of Concept Grant (PoC) comes with a few adaptions in Horizon Europe. PoC Proposals will be evaluated based on excellence only, assessed from three angles: breakthrough innovation potential, approach and methodology, and capacity and commitment of the PI. Exceptionally, the Work Programme 2022 offers two distinct PoC Calls, to compensate for the lack of a PoC Call in Work Programme 2021. The first call, ERC-2022-PoC1, is equipped with a EUR 25 million budget and a single cut-off date on 14 October 2021 (eligibility reference date: 1 January 2021). The second Call, ERC-2022-PoC2, also endowed with budget of EUR 25 million, features 3 cut-off dates, namely 15 February, 19 May and 29 September 2022 (eligibility reference date: 1 January 2022).